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A Boolean maximum constraint satisfaction problem, Max-CSP(f), is specified by a predicate f:{-1,1}^k → {0,1}. An n-variable instance of Max-CSP(f) consists of a list of constraints, each of which applies f to k distinct literals drawn from the n variables. For k = 2, Chou, Golovnev, and Velusamy [Chou et al., 2020] obtained explicit ratios characterizing the √ n-space streaming approximability of every predicate. For k ≥ 3, Chou, Golovnev, Sudan, and Velusamy [Chou et al., 2022] proved a general dichotomy theorem for √ n-space sketching algorithms: For every f, there exists α(f) ∈ (0,1] such that for every ε > 0, Max-CSP(f) is (α(f)-ε)-approximable by an O(log n)-space linear sketching algorithm, but (α(f)+ε)-approximation sketching algorithms require Ω(√n) space. In this work, we give closed-form expressions for the sketching approximation ratios of multiple families of symmetric Boolean functions. Letting α'_k = 2^{-(k-1)} (1-k^{-2})^{(k-1)/2}, we show that for odd k ≥ 3, α(kAND) = α'_k, and for even k ≥ 2, α(kAND) = 2α'_{k+1}. Thus, for every k, kAND can be (2-o(1))2^{-k}-approximated by O(log n)-space sketching algorithms; we contrast this with a lower bound of Chou, Golovnev, Sudan, Velingker, and Velusamy [Chou et al., 2022] implying that streaming (2+ε)2^{-k}-approximations require Ω(n) space! We also resolve the ratio for the "at-least-(k-1)-1’s" function for all even k; the "exactly-(k+1)/2-1’s" function for odd k ∈ {3,…,51}; and fifteen other functions. We stress here that for general f, the dichotomy theorem in [Chou et al., 2022] only implies that α(f) can be computed to arbitrary precision in PSPACE, and thus closed-form expressions need not have existed a priori. Our analyses involve identifying and exploiting structural "saddle-point" properties of this dichotomy. Separately, for all threshold functions, we give optimal "bias-based" approximation algorithms generalizing [Chou et al., 2020] while simplifying [Chou et al., 2022]. Finally, we investigate the √ n-space streaming lower bounds in [Chou et al., 2022], and show that they are incomplete for 3AND, i.e., they fail to rule out (α(3AND})-ε)-approximations in o(√ n) space. 

A novel method based on atomic force microscopy (AFM) working in Ringing mode (RM) to distinguish between two similar human colon epithelial cancer cell lines that exhibit different degrees of neoplastic aggressiveness is reported on. The classification accuracy in identifying the cell line based on the images of a single cell can be as high as 94% (the area under the receiver operating characteristic [ROC] curve is 0.99). Comparing the accuracy using the RM and the regular imaging channels, it is seen that the RM channels are responsible for the high accuracy. The cells are also studied with a traditional AFM indentation method, which gives information about cell mechanics and the pericellular coat. Although a statistically significant difference between the two cell lines is also seen in the indentation method, it provides the accuracy of identifying the cell line at the single‐cell level less than 68% (the area under the ROC curve is 0.73). Thus, AFM cell imaging is substantially more accurate in identifying the cell phenotype than the traditional AFM indentation method. All the obtained cell data are collected on fixed cells and analyzed using machine learning methods. The biophysical reasons for the observed classification are discussed.